Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Treatment with exogenous TGF‑β1 attenuated the inhibitory effect of LINC01638 shRNA silencing on cancer cell migration and invasion. 31702018

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Human and mouse cancer associated fibroblasts (CAFs) in liver metastasis were separated to culture to study the interaction of LOX and TGF-β1. 31678002

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In particular, increase in the invasion ability of MSCs by TGF-β1 and decrease in p53, which plays a key role in cancer development, is an important discovery. 31601153

2020

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE MIR4435-2HG overexpression and treatment with TGF-β1 promoted cancer cell invasion and migration. 31516603

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Multivariable logistic regression of cancer status in an over-dominant TGFB1 rs1800469/TGFBR1 rs11568785 model demonstrated a 3.03-fold reduction in cervical cancer odds. 31435875

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE TGFB1 was involved in more pathways, such as proteoglycans in cancer, malaria, and amebiasis. 31356112

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE It is known that lncRNA GASL1 can inactivate TGF-β1 in cancer biology. 31223316

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE The differential modulation of important cellular pathways like TGF-β1 and STAT1 can explain the sensitivity of tissues to HPV cancer progression.<b>IMPORTANCE</b> Although the high-risk human papillomavirus 16 infects anogenital and oropharyngeal sites, the cervical epithelium has a unique vulnerability to progression of cancer. 31189705

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE The plasma expression levels of snaR and TGF-β1 were positively correlated in patients with HCC; however, not in healthy controls. snaR overexpression significantly promoted cancer cell migration and invasion, and additionally increased TGF-β1 expression. 31186778

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE The TG-interacting factor 1 (TGIF1) gene, which encodes a nuclear transcriptional corepressor of the TGFβ1/Smad signaling pathway, has been implicated in the pathogenesis of various types of human cancer; however, its role in pancreatic ductal adenocarcinoma (PDAC) has yet to be elucidated. 31109321

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In-vitro Pre-Treatment of Cancer Cells with TGF-β1: A Novel Approach of Tail Vein Lung Cancer Metastasis Mouse Model for Anti-Metastatic Studies. 30848226

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE The observations in this study identify an important regulatory mechanism of fascin-1 in BLCA, and the TGF-β1/ZEB1-AS1/miR-200b/FSCN1 axis may serve as a potential target for cancer therapeutic purposes. 30823924

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Tumor cell epithelial-mesenchymal transition (EMT), which can be induced by transforming growth factor β1 (TGFβ1), has been regarded as a significant contributor to cancer invasion and migration. 30635938

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE TGF-β1 inhibitor partially rescued the inhibited cancer cell migration and invasion caused by lncRNA POU3F3 overexpression. 30602452

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). 30594239

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE GASL1 overexpression and knockdown cancer cell lines were constructed and the effects on transforming growth factor β1 (TGF-β1) expression and cell proliferation were explored by Western blot and CCK-8 assay, respectively. 30468472

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Transforming growth factor β 1 (TGFB1) likely contributes to the pathogenesis of Epstein-Barr virus (EBV)-mediated cancer. 30465450

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Transforming growth factor-β1 (TGF-β1) is one of very few cytokines produced in a latent form, requiring activation to exert any of its vastly diverse effects on development, immunity, and cancer. 30361387

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Down-regulation of lncRNA snaR effectively distinguished HPV-negative CSCC patients from healthy controls. lncRNA snaR was further down-regulated in patients with distant recurrence (DR) but not in patients with local-recurrence or without recurrence. lncRNA snaR overexpression decreased TGF-β1 expression in CSCC cells, while exogenous TGF-β1 treatment showed no significant effects on lncRNA snaR expression. lncRNA snaR overexpression inhibited cancer cell migration and invasion, while TGF-β1 treatment attenuated the inhibitory effect of lncRNA snaR overexpression on cancer cell migration and invasion. 30249756

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Stimulation of cancer cells with TGF‑β1 weakened the ability of glioblastoma cells to attract HSCs and exchange a fluorescent tag. 30226551

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE TGF-β1 may accelerate cancer cell energy metabolism to promote the growth of hepatocellular carcinoma by upregulating UCA1 and its downstream HXK2. 30070319

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Moreover, TGFβ1 was able to enhance the mRNA expression of Oct4, Nanog and Sox2 and drastically increased anchorage-independent colony formation in TGFβ1-sensitive NSCLC cells, suggesting the acquisition of cancer stem-like properties. 29995950

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Markers relevant for bulk cancer cell migration were regulated differently when compared with EMT: Twist expressed in primary tumour, invasion front, and metastasis was not associated with TGFβ1 and canonical Wnt, as Slug, Snail, and Smads were negative and β-Catenin expressed membraneously. 29976164

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE We here review the role of TGF-β1 and Smad7 in intestinal immunity, inflammation, and cancer. 29973939

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Here, we used genetic engineering to generate a stable SMAD3-silencing human NK cell line, NK-92-S3KD, whose cancer-killing activity and cytokine production were significantly enhanced under TGFβ1-rich condition compared with the parental cell line. 29915022

2018